The Dohmeyer Pelletizer instantly freezes droplets of enzymes or bacterial cultures using liquid nitrogen at –196°C, forming uniform cryo-pellets. It preserves bioactivity, ensures precise dosing and supports applications in dairy, bakery, brewing, pharma, and research. Ideal for small to large-scale production, it offers clean, reliable and scalable cryogenic pelletizing.
Wide range of sizes available
The Dohmeyer Cryogenic Pelletizer transforms high-value liquid substances into uniform, free-flowing ice pellets. Designed for the biotechnology, pharmaceutical, and specialized food sectors, this system utilizes a precision dosing mechanism to dispense droplets directly into a bath of liquid nitrogen at –196°C. Upon contact, each droplet freezes instantly into a spherical pellet, rapidly reaching temperatures below –40°C. This ultra-fast thermal exchange is critical for preserving the cellular integrity, bioactivity, and complex structures of sensitive materials like enzymes, probiotics, and viral vectors. By eliminating slow freezing phases, the Pelletizer prevents cellular degradation and ensures reliable performance after thawing. Capable of operating in both batch and continuous modes, the system easily scales from R&D laboratory setups to high-throughput industrial production lines, delivering consistent pellet sizing without generating wasteful satellite droplets.
In high-value liquid processing, operational efficiency relies on minimizing cryogen waste and maximizing product yield. The Dohmeyer Pelletizer achieves industry-leading efficiency by ensuring that only the precisely formed droplets are subjected to the freezing process, rather than chilling the entire bulk volume. This targeted heat transfer results in exceptionally low liquid nitrogen (LN₂) consumption per kilogram of processed product. Furthermore, the uniform, spherical nature of the resulting pellets guarantees highly accurate downstream dosing and blending. Because the pellets are completely free-flowing and consistent in size, processors experience significantly reduced product loss during packaging, freeze-drying, or sublimation stages. This optimized thermodynamic design lowers the overall energy footprint of the production line and accelerates the return on investment by drastically reducing ongoing cryogenic consumable costs.
Operating with liquid nitrogen at –196°C demands a robust safety architecture to protect facility personnel and maintain process stability. The Dohmeyer Pelletizer incorporates advanced, multi-layered safety protocols to manage the deep-cryogenic temperatures and rapid gas expansion inherent to the pelletizing process. The system is designed to integrate directly with factory exhaust infrastructure to safely capture and evacuate nitrogen vapors, effectively preventing any risk of oxygen depletion in the workspace. Automated control valves and vacuum-insulated piping ensure that the delivery of liquid nitrogen is carefully regulated, immediately mitigating overpressure scenarios. Additionally, continuous temperature monitoring and integrated emergency shutdown mechanisms guarantee that the machine operates strictly within set parameters. Through these highly engineered measures, plant managers can deploy ultra-low temperature freezing while fully complying with stringent industrial safety regulations.
For the pharmaceutical, cryobiological, and dairy industries, microbial stability and cross-contamination prevention are absolute necessities. The Dohmeyer Cryogenic Pelletizer is constructed following a rigorous clean-by-design philosophy. For high-risk applications involving cell cultures or gene therapy vectors, Dohmeyer offers a specialized version of the Pelletizer that is entirely CIP/SIP (Clean-In-Place / Sterilize-In-Place) compatible. This allows the internal processing zones to be automatically cleaned and steam-sterilized without manual disassembly, facilitating a completely aseptic production environment. Once the transitional temperature is reached, the pellets are mechanically extracted from the nitrogen bath and can be directly deposited into sterile vials, containers, or reactors for downstream use. By integrating these advanced sanitation capabilities, the Pelletizer drastically reduces cleaning downtime and ensures full compliance with strict regulatory standards.
The modern processing landscape requires equipment capable of adapting to diverse product portfolios, from biopharma suspensions to consumer ice treats like Mini Melts. The Dohmeyer Pelletizer delivers exceptional manufacturing flexibility through its modular architecture and precise control systems. The precision dosing module can be finely adjusted to handle liquids with varying densities, including lactobacilli cultures, emulsified proteins, and fruit-based syrups, guaranteeing accurate droplet formation across different recipes. Operators can seamlessly switch between processing pharmaceutical ingredients and food-grade starter cultures using intuitive controls. Because the system is engineered for scalability, manufacturers can initially deploy the unit for small-batch clinical trials, and efficiently scale up to continuous, full-scale manufacturing without altering the core freezing dynamics, ensuring complete product consistency at any capacity.
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