The CryoXpert Cryogenic Carousel Control Rate Freezers are specially developed to fulfill the most demanding need for freezing or cooling of biological and pharmaceutical products. The cabinet are mainly used for rapid and controlled freezing of living biomedical materials. CryoXpert controlled rate freezers have been successfully installed in the human and veterinarian vaccine production on large scale. But also for small and largescale cryopreservation of gametes (semen, ovum), embryos and otocysts.
In the highly demanding medical and biopharmaceutical sectors, safeguarding the viability of biological samples requires a reliable and rigorously tested thermal management system. The CryoXpert Carousel Controlled Rate Freezer stands as a proven solution designed specifically to address the challenges of high-throughput cryogenic processing. Engineered by the medical division of Dohmeyer, the world leader in rapid cooling technology, this advanced unit is capable of homogeneously freezing over 40,000 standard 2ml vials in a single batch. Available in multiple volumetric capacities ranging from the 10,000-vial CXP-CAB-10K to the massive 40,000-vial CXP-CAB-40K the freezer provides scalable options tailored to specific facility requirements. By operating within a meticulously controlled and continuously monitored environment, the system guarantees that high-value biological products maintain their structural integrity and ultimate viability post-thawing. This robust architecture delivers unmatched precision, ensuring consistent processing outcomes for facilities that cannot afford compromises in product quality.
A critical vulnerability in batch freezing processes is the thermal fluctuation introduced when operators need to access specific samples. The CryoXpert Carousel Controlled Rate Freezer actively mitigates this risk through its highly innovative, rotating carousel architecture. This unique internal design allows operators to index and access each sample individually without exposing the remaining vials to ambient room temperatures. By ensuring that the primary batch remains securely within the deep-freeze environment, the system effectively guarantees an uninterrupted cold chain and prevents dangerous temperature spikes. Furthermore, thermal containment is reinforced by a specialized heated door and doorframe configuration, which creates a gas-tight seal while entirely eliminating the risk of condensate drips that could lead to hygiene breaches. Supported by a redundant safety loop that provides a full secondary backup to the primary circuit, the freezer delivers secure, continuous operation and absolute thermal consistency.
Handling critical pharmaceutical liquids and biological samples mandates absolute adherence to international safety and data integrity standards. Manufactured by an ISO 13485 certified company, the CryoXpert Carousel Controlled Rate Freezer operates strictly within GMP guidelines to ensure the highest level of processing security. A cornerstone of its compliance architecture is its full alignment with 21 CFR Part 11 regulations. The system features a sophisticated password-protected and RFID card-based operating panel, guaranteeing that only authorized personnel can access or modify critical freezing functions. To eliminate the possibility of data manipulation and ensure a reliable audit trail, the machine automatically generates encrypted PDF process reports. Additionally, the integration of an Uninterruptible Power Supply (UPS) acts as a vital safeguard for data protection, providing a dependable secondary power source to mitigate data loss and sustain critical monitoring systems during facility power interruptions
Biological products respond differently to temperature reductions, requiring highly adaptable thermodynamic profiles. The CryoXpert Carousel Controlled Rate Freezer utilizes an advanced vacuum-insulated manifold equipped with a proportional process valve and a safety shut-off valve, granting operators the flexibility to finely adjust freezing parameters. Supported by highly calibrated process and product temperature probes, the system allows for the creation of precise freezing curves that contribute to shorter overall freeze times and significantly reduced cryogen consumption without compromising product stability. Crucially, the internal geometry and air circulation promote highly homogeneous freezing, ensuring uniform temperature distribution across the entire chamber meaning the vial at the center of the carousel freezes identically to those on the periphery. Finally, an automatic defrosting system ensures a rapid return to initial ambient temperatures in the chamber, allowing for fast, repetitive freezing cycles that drastically improve overall facility throughput.
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